Mouse Anti-Human TLR6-UNLB MBS670143 from MyBioSource.com

Product Specs
ItemMouse Anti-Human TLR6-UNLB
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS670143
Quantity0.1 mg
ApplicationsELISA; Flow Cytometry
FormatPurified (UNLB) Antibody
ReactivityHuman
ClonalityMonoclonal
IsotypeIgG2a
Clone3B6
HostMouse
ImmunogenHuman Toll-like Receptor 6 (TLR6)
The Toll-like receptor (TLR) family is comprised of Type I transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail that contains a conserved region call the Toll/IL-1 (TIR) domain. First discovered in Drosophila, TLRs recognize specific molecular patterns that are present in microbial components and respond to these components in order eliminate or limit invading microbes. To date, ten mammalian homologs of TLRs have been described. TLRs signal through adaptor molecules such as MyD88 leading to NF- kappa B activation, c-Jun N-terminal kinase activation (JNK), cytokine secretion and the inflammatory response. The amino acid sequence of human TLR6 is most similar to hTLR1 with 69% identity. TLR6 recognizes mycoplasmal macrophage-activating lipopeptide- 2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B. burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.1-6
NCBI Full Gene Nametoll-like receptor 6
NCBI Gene AliasesCD286
Conjugate/TagUnconjugated
TargetToll-like Receptor 6 (TLR6)